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Enzymatic vs. Fluorescence Sensing Technology
CGM technologies include enzymatic sensing (traditional) and fluorescence sensing, each with distinct advantages for glucose detection.
Enzymatic vs. Fluorescence Sensing Technology
Two Approaches to Glucose Detection
Continuous Glucose Monitors use different sensing technologies to detect glucose levels.
Enzymatic Sensing
How It Works
Glucose oxidase breaks down glucose, producing an electrical signal through electrochemical reaction.
Advantages
- Well-established technology
- High accuracy
- Proven track record
Disadvantages
- Prone to certain interferences
- Limited sensor lifespan due to enzyme degradation
Fluorescence Sensing
How It Works
A fluorescent molecule binds to glucose, changing its light emission intensity. This change is measured to determine glucose levels.
Advantages
- Less interference from electroactive substances
- Potentially longer sensor lifespan
- No oxygen dependency
Disadvantages
- Newer technology with less real-world data
- Generally higher cost
- May require different insertion/application methods
Market Examples
- Most current CGMs use enzymatic sensing
- Some emerging technologies explore fluorescence-based approaches