Enzymatic Chemistry: GOx vs. GDH
Two key enzymes power CGM sensors: Glucose Oxidase (GOx) offers superior specificity while Glucose Dehydrogenase (GDH) provides different performance characteristics.
Enzymatic Chemistry: GOx vs. GDH
The Core of Glucose Detection
Enzymatic chemistry drives continuous glucose monitors. Two key enzymes are at play.
Glucose Oxidase (GOx)
How It Works
GOx catalyzes glucose, producing gluconic acid and hydrogen peroxide. Electrodes measure the hydrogen peroxide to calculate glucose levels.
Key Advantage
GOx targets glucose only—excellent specificity.
Glucose Dehydrogenase (GDH)
How It Works
GDH catalyzes glucose, producing an electron transfer that is directly measured to indicate glucose levels.
Key Consideration
GDH is less specific and may be affected by other substances.
Comparison
| Feature | GOx | GDH | |---------|-----|-----| | Specificity | High | Moderate | | Interference resistance | Good | Variable | | Sensor longevity | Longer | May need more calibration | | Oxygen dependency | Yes (traditional) | No |
Choosing Between Them
Modern sensor design often favors GOx with mediator chemistry (wired enzyme), combining the specificity of GOx with reduced oxygen dependency.